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I believe that the title is self-contained. Does make sense to use t-SNE and then applied HDBSCAN to cluster the data with dimensionality reduction?

HenDoNR
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tSNE is NOT a Dimensionality Reduction algorithm but a Visualization method.

The reason is that it is non-parametric and can not model a new data in the same way. What you are looking for is UMAP and yes, you can reduce dimensionality and use a clustering method to find clusters (indeed this is a common practice in clustering)

Kasra Manshaei
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